Acetaminophen Safety in the News

  • In the U.S., acetaminophen overdose has not only replaced viral hepatitis as the most common cause of acute liver failure, but it’s also the second most common cause of liver failure requiring liver transplants. Acetaminophen Toxicity
  • The U.S. Food and Drug Administration (FDA) is asking manufacturers of prescription combination products that contain acetaminophen to limit the amount of this ingredient to no more than 325 milligrams (mg) in each tablet or capsule to make them safer for patient use. Because of continued reports of liver injury, the FDA is requiring manufacturers to update labels of all prescription combination acetaminophen products to warn of the potential risk for severe liver injury. FDA Limits Acetaminophen in Prescription Combination Products; Requires Liver Toxicity Warnings
  • According to the U.S. Food and Drug Administration, 56% of acetaminophen overdose occur when OTC acetaminophen is taken with prescription pills like Vicodin® and Percocet®, which also include acetaminophen. Update: New Acetaminophen Overdose Concerns
  • Acetaminophen overdose causes more than 400 deaths due to acute liver failure each year in the U.S. The Debate over Acetaminophen and Acute Liver Failure
  • People who take large quantities of medications that contain acetaminophen over several days – usually to relieve pain and often in conjunction with other narcotics – are typically not aware of potential harm and only seek treatment after overdose symptoms have appeared and their prognosis is poor. These cases constitute about half of all cases that develop liver failure, and 30% of all these cases are fatal. The Debate Over Acetaminophen and Acute Liver Failure