FDA Requires MedGuide with Accutane

Pharmacists must distribute to all Accutane patients a new Medication Guide (MedGuide) each time a prescription is dispensed. Further, a detailed Informed Consent / Patient Agreement must be signed by both patients and their physician. The form includes statements addressing risks associated with being pregnant while on Accutane, and the potential for psychiatric events.
http://www.fda.gov/cder/drug/infopage/accutane/medicationguide.htm